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Randomized, double-blind, placebo-controlled phase 3 study of bardoxolone methyl in patients with diabetic kidney disease: design and baseline characteristics of AYAME study

Lighter skin tone: This usually prevents further distribution of the darker pigment, thus having a radiant lighter skin tone

However, this improvement appeared domain-specific, as no significant differences were observed in working memory

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Despite the possibility that additional mechanisms are also at play, the regulation of catalase expression seems to be primarily controlled at the transcriptional level